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Their symptoms included the full range of psychological and physical symptoms usually described as benzodiazepine withdrawal symptoms

To further explore the relationship between the LVEF at baseline and the dual primary endpoints (changes in KCCQ-CSS and body weight) in a more granular fashion, we employed mixed models incorporating LVEF as a continuous variable with a quadratic spline by randomized treatment adjusted for corresponding endpoints at baseline, all nested within visits and using in-trial data

Safety profiles in adults 1875 years old show similar tolerability, with gastrointestinal side effects declining after 48 weeks of therapy

acknowledges support from the NIH (R24DK082841 and R01D107956) and the NovoNordisk Foundation (NNF14OC0011633)

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Leptin levels decrease as fat mass reduces, whilst ghrelin (the 'hunger hormone') increases, creating a biological drive to restore lost weight