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The commercial players are real, just not the loudest, only the most motivated
The binding pocket resides the catalytic threonine at the bottom of the groove on one of the central -sheets, and it further extends into the enzyme, appearing as a finger-like projection
Phytomedicine, 13 (8), 550557
8.3 Curcumin and its pleiotropic effects against TBI Curcumin, a polyphenol derived from turmeric, has emerged as a potential neuroprotective phytochemical for TBI owing to its multifaceted effects
Zorn and Baillie, 2023
That rules out, straightforwardly, radioligand or fluorescent binding assays, competition binding against a known ligand, recombinant receptor-expressing lines, functional readouts tied to a defined coupling pathway, and antagonist controls to demonstrate that an effect is receptor-mediated
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