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Assessed parameters included cardiomyocyte occupancy, extracellular matrix, inflammatory cell infiltration, blood vessels, and processing artifacts

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The inhibition of prostaglandins in the central nervous system also raises the pain threshold and acts on the hypothalamus to reduce body temperature (Amar 2007)

Another central feature is the loss of protein balance, especially involving TDP-43, a protein that is abnormally located in the cytoplasm instead of the nucleus in about 97% of ALS cases