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In terms of taking time off from work or social events, almost all of these treatments have no downtime whatsoever (except the CO2 Laser treatments which are really reserved for the most severe cases)

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The most common formula, known as MIC B12, combines methionine, inositol, choline, and vitamin B12, all of which play specific roles in fat metabolism, liver function, and energy production

Retrieved 10 January 2020

In fact some research suggests that B12 analogues may compete with B12 leading to the metabolism being inhibited

Difficulty swallowing or breathing (anaphylaxis) is also possible