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Several systematic reviews also indicated that GLP-1RAs are consistently effective at reducing body weight [25, 41, 42, 44], supporting the nonglycaemic role of this agent class [44], as opposed to the weight gain that commonly accompanies insulin treatment [44]

I've been lucky enough to have no negative side effects, and I've been able to lose around 100 pounds and am solidly within the 'healthy' BMI range." "The weight loss was achieved entirely through diet, but in the last several months I've added more exercise to my daily routine and have started weightlifting and training several times a week at the gym." Anonymous, 36, Female, Arkansas 9

Another study assessing beta-cell sensitivity to GLP-1 in lean and obese individuals found that beta-cell responsiveness to it was proportional to insulin resistance

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