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To ensure optimal absorption and effectiveness, Rybelsus should be taken at least 30 minutes prior to the first consumption of food, beverages, or other oral medications of the day, with no more than 4 ounces of plain water

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By contrast, compounded semaglutide comes in pills, sublingual tablets, and suspension (liquid) or vials that often require users to measure each dose

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While it is unknown if this occurs in humans, those with a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use these medications