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10.1136/ard.43.3.462 9 BegumR.ThotaS.AbdulkadirA.KaurG.BagamP.BatraS
Cognitive Enhancement Studies Cognitive improvement studies in 28-month-old mice (equivalent to elderly humans) using 10 mg/kg body weight administered 5x per week for 3 weeks demonstrated: Significantly faster escape hole finding in Box Maze tests (trials 4 and 5) Evidence of decreased brain inflammation Increased histone deacetylase 2 labeling indicating epigenetic pathway activation Preliminary reversal of age-related cognitive impairment Pain and Anxiety Modulation Anti-pain effects in mice at 0.5 mg/kg showed efficacy comparable to cimetidines human analgesic effects, affecting 7 anti-pain genes (increased) and 2 genes (decreased), with upregulated opioid receptors and related pain-modulating pathways
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Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes
(2020) and Qiang and Cheng, 2019 found that plastic additives resulted in alterations in the swimming behavior of zebrafish and juvenile yellow perch feeding behavior, respectively
The stability and time persistence of these wines is also improved by the microbial control through emerging non-thermal technologies, the bioprotection and acidification produced by some of the non- Saccharomyces species discussed above, allowing the reduction of SO 2 levels
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