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You trade GI problems for potential tingling, cognitive effects, and insomnia
Notably, these effective concentrations were 16,000-80,000,000 times lower than concentrations of melatonin required for comparable effects, suggesting highly potent regulatory mechanisms rather than simple antioxidant activity
Genetic predisposition is one factor
One major disadvantage of this type is that it gets depleted by stomach acid when taken orally
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Although, autoantibodies against serotonin have been associated with ME/CFS (506, 508)
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