10.1073/pnas.0611533104 Proc
Microbial metabolites such as short-chain fatty acid (SCFAs) and indole derivatives, can act locally on enteroendocrine and immune cells and, after absorption, modulating appetite, hepatic glucose production, peripheral insulin sensitivity and systemic inflammation (79)
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Aggressive protocols deliver faster pigmentation but have 4050% higher discontinuation rates due to intolerable nausea during loading