Arbabi L, Li Q, Henry BA, Clarke IJ (2021) Glucagon-like peptide-1 control of GnRH secretion in female sheep
In a combined HRT regimen, progesterones critical role is to counteract the effect of oestrogen on the womb lining, preventing endometrial thickening
Other GLP-1 agonists include: Trulicity (dulaglutide) Victoza (liraglutide) Bydureon (exenatide) Adlyxin (lixisenatide) Mounjaro (tirzepatide) Other diabetes medications are also available
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The NIH's general framework for peptide pharmacokinetics confirms that hepatic contribution to small peptide clearance varies widely, from negligible to dominant, depending on lipophilicity and plasma protein binding
It does what it claims to do for some users, but the results are inconsistent and the value proposition is debatable