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We hypothesise that GLP-1 receptor activation may inhibit proinflammatory mediators, which are elevated in people with psoriasis
The GnRH receptor is also found in certain cancers, and the reduction in circulating estrogen slows the growth of hormone receptor-positive tumors such as ovarian cancer 117 , prostate cancer 118 , and breast cancer 119,120,121
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In a landmark Phase 2 trial, patients receiving the highest dose of retatrutide (12 mg) achieved an average weight loss of 24.2% after 48 weeks
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