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10.1038/s41598-019-47642-2 38 FangC.WangS

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Reuptake and Metabolic Inhibition : Ephedrine prolongs the residency of norepinephrine in the synaptic cleft by weakly inhibiting NET-mediated reuptake and demonstrating a weak inhibitory effect on mitochondrial monoamine oxidase (MAO), the primary enzyme responsible for catecholamine degradation (Statler et al, 2023)

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Therefore, activating GPX4 and GSH to inhibit ferroptosis is an attractive option for cardiac disease therapy (Fig