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The main active ingredient is glutathion, one of the major peptide synthesized in human cells

These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints (1518, 71)

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Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis status

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GSH levels were measured in the ELF, bronchoalveolar lavage cells, plasma, and tissues