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What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide
Bacteriostatic or Sterile water is required to reconstitute the peptide
In Dubin-Johnson syndrome, around 90% is coproporphyrin 1 but the percentage is much lower in Rotor syndrome
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Problem : Degrades within days, loses effectiveness
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