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In the ischemic core, irreversible ATP depletion and severe acidosis limit the potential for cellular rescue
However, if metformin is still not tolerated, the presence (or absence) of comorbidities helps inform the choice of alternative medications
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
(Eds) Laron SyndromeFrom Man to Mouse (Springer, 2011)
Interestingly, glutathione helps "recharge" Vitamin C after it has neutralized a free radical
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