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PRO Observations From the PIONEER Program Observations for SF-36v2 ETDs between oral semaglutide and comparators for SF-36v2 domain scores in PIONEER 2, 5, and 8 are shown in Figure 1

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98 Although located in the sinoatrial node, GLP-1 RAs influence the cardiovascular system through several other mechanisms, including the use of myocardial glucose, improvement of left ventricular function, myocardial ischaemic protection, increased heart rate, vasodilation, anti-atherosclerotic effects, and blood pressure reduction

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