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A 2003 study by Staresinic et al

Response timelines vary

And it provides the medium where bacteria can grow, introducing biological contamination on top of chemical degradation

It is usually combined with other forms of therapy, such as balance training or strengthening exercises, to maximize results

For the Achilles tendons watershed zone where natural vascularity is poor, this enhanced blood supply can make the difference between successful healing and chronic tendinopathy

Additionally, the long-term effects of melanocortin receptor stimulation are unknown, raising concerns about cardiovascular and other systemic effects