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To ensure blinding integrity, assessors were instructed not to discuss treatment details with patients, and patients were advised not to disclose their treatment to assessors

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Breast cancer cells can develop metformin resistance by triggering IGF-1R target insulin receptor substrate-1 (IRS-1)/ERK signaling through overactivation of FGFR1

One potential indirect mechanism involves severe gastrointestinal adverse effects

Follow Instructions: The dose and schedule are strictly determined by the doctor based on your blood test results and clinical status