Approaches include redox interactions with high-valent metal ions (like Cu 2 and Fe 3 ), suppression of GSH synthesis using agents such as BSO, the use of nanozymes that mimic enzymatic activity, and direct GSH neutralization through molecular binding [18]
Lipoic acid prevented NOX-induced superoxide production in a rat model of cerebral ischemia and limited infarct volume and neurological deficiencies through upregulating the insulin-phosphatidylinositide-3 kinase (PI3K)-protein kinase B (PKB/Akt) signaling pathway (40)
The activated STAT proteins may then translocate to the nucleus, where they might bind to specific DNA sequences called response elements, possibly leading to the transcription of the IGF-I gene
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Umweltwiss Schadst Forsch 17(1):5053 Sandermann H (1994) Higher plant metabolism of xenobiotics: the green liver concept