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Approaches include redox interactions with high-valent metal ions (like Cu 2 and Fe 3 ), suppression of GSH synthesis using agents such as BSO, the use of nanozymes that mimic enzymatic activity, and direct GSH neutralization through molecular binding [18]

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Lipoic acid prevented NOX-induced superoxide production in a rat model of cerebral ischemia and limited infarct volume and neurological deficiencies through upregulating the insulin-phosphatidylinositide-3 kinase (PI3K)-protein kinase B (PKB/Akt) signaling pathway (40)

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The activated STAT proteins may then translocate to the nucleus, where they might bind to specific DNA sequences called response elements, possibly leading to the transcription of the IGF-I gene

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Umweltwiss Schadst Forsch 17(1):5053 Sandermann H (1994) Higher plant metabolism of xenobiotics: the green liver concept

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