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The free tripeptide GHK occurs naturally in human plasma, saliva and urine, and was first isolated from plasma by Loren Pickart in 1973
doi: 10.1007/s43440-022-00402-y 23
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Melanotan II acts as a non-selective agonist with nanomolar-range affinity at MC1R, MC3R, MC4R, and MC5R, with relative potencies varying by assay system but generally showing highest functional activity at MC1R and MC4R in cAMP accumulation assays using transfected cell lines
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