Its called stage 0 because there are many people who dont even know that they are in this stage
Cellular Repair : By combating oxidative stress, glutathione supports the repair of damaged cells and tissues, thereby contributing to longevity and vitality
Figure 1 2 Potential mechanisms by which the oral-gut axis influences systemic health The oral and gut microbiomes are interconnected via a dynamic bidirectional relationship termed the oral-gut axis
Meta-regression The meta-regression results indicated that the coefficient of MACE for metformin use was estimated as at 0.1436 (95%CI 0.0095, 0.2967), suggesting a potential positive effect of metformin on the outcome, but did not reach statistical significance ( P = 0.0661)
That has been true for retatrutide as well, according to recent study results
However, data are lacking to back up their theory [48]