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While tirzepatide preserves lean mass better than diet alone, some researchers look for ways to further protect muscle during aggressive weight loss

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Importantly, hepatocytes have developed defenses to mitigate the detrimental buildup of ROS within the cell, and GSH-coordinated antioxidant systems, such as catalase, glutathione peroxidase, and superoxide dismutase, play essential roles in this regard (Imaizumi and Aniya, 2011)

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Collective findings from these studies underscore persistent translational challenges, including size heterogeneity, rapid renal clearance, and limited long-term toxicological data, highlighting the need for improved targeting, surface modification, and synthesis control to support clinical translation [190]