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Berberine has demonstrated anti-inflammatory and antioxidant properties and current research is focusing on its potential for use with diabetes, obesity, PCOS, and fertility, to name a few (2)

In the TMLHE gene knockout mouse model, the carnitine biosynthetic pathway is inhibited due to the loss of TMLD activity in the liver, affecting the availability of carnitine in the heart, significantly reducing the rate of synthesis of LCACs, and contributing to the protection of mitochondrial function after myocardial IRI [215]

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L-carnitine is an amino acid that is necessary for heart muscle cells to make the energy needed for them to contract