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Some trials show small rises in GLP-1 with certain fats, others do not

Here's How GLP-1 Interacts Key point: GLP-1 slows stomach emptying, which means all oral medications may absorb differently

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In a single and crossover trial involving 2,374 participants, the results of Omega-3 PUFA plus atomoxetine was compared with atomoxetine and Omega-3 or Omega-6 supplementation plus methylphenidate-methylphenidate, and the results of the two trials found that low-quality PUFAs may improve ADHD symptoms in the medium term, but there was no difference with higher doses compared to placebo (123)

They can also lead to muscle loss, which would be concerning for SUD patients if the off-target effects continue outside of obesity and diabetes

FDA (2024) 8