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While typically administered as a subcutaneous injection, epithalon is also available in nasal spray preparations

Impact of HER2 heterogeneity on treatment response of early-stage HER2positive breast cancer: phase II neoadjuvant clinical trial of T-DM1 combined with pertuzumab

Trends Biotechnol 13:527537

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MAPK signaling contributes to therapeutic resistance by enhancing the expression of drug efflux transporters such as MDR1 and P-gp and by upregulating antiapoptotic genes such as Bcl-2