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Tirzepatide (Zepbound) showed even more impressive results in the SURMOUNT-1 trial, published in the New England Journal of Medicine in 2022

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[242] [243] [244] Some evidence suggests that amphetamine may be more strongly modulated by ovarian sex hormones than other psychostimulants such as methylphenidate, which may result in relatively greater variability in drug response across the menstrual cycle

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