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Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes

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Glutathione levels and miscarriage [PMID: 11119764] Laboratory literature summary: Glutathione levels and miscarriage