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Effects of the sodium-glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and stages 3b-4 chronic kidney disease

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Reactive oxygen species (ROS) were measured using the laser confocal scanner and glycolysis was detected using an Agilent Seahorse kit

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Tissue hypoxia and oxidative stress also can contribute to non-immune mediated tissue injury driven by renal stromal cells, further enhancing interstitial immune cell infiltration and fibrosis to create a viscous cycle3

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