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Initially, research on senotherapeutics focused on age-related diseases [98]

doi: 10.1371/journal.pone.0023307 86 Miller-WilliamsM.LoewenP

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Abstract Cirrhosis-related Parkinsonism is a frequent but often overlooked neurological complication of chronic liver disease, primarily driven by manganese (Mn) accumulation in the basal ganglia resulting from portosystemic shunting

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A study on diet-induced obese (DIO) mice demonstrated that a reduced-calorie diet combined with NNMT inhibition resulted in a unique microbiome composition, suggesting potential applications for 5-Amino-1MQ in gut microbiota-related metabolic research