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By enhancing endogenous melatonin production, DSIP optimizes the sleep cycle without the need for supplements, making it particularly valuable in the management of insomnia and other sleep disorders

This encompasses collagen induction, promotion of wound healing, antioxidant effects, inhibition of inflammatory cytokines, and promotion of skin repair

PDRN inhibits melanogenesis through downregulation of microphthalmia-associated transcription factor (MITF), and the 2024 Tsai split-face RCT demonstrated significant melasma severity reduction with combined microneedling radiofrequency and depigmenting agents in Fitzpatrick III and IV patients

Glutathione is an antioxidant it neutralizes free radicals, inhibits melanin synthesis for skin brightening, and supports liver detoxification

Cureus / PMC (2024) 9