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Melanosis coli (MC) is a noninflammatory bowel entity in which a brown or black pigment is deposited in the colorectal mucosa
Doctors know the full dose works, they know stopping fails, and they reason their way into the unmapped territory in between using how these drugs behave in the body and a lot of accumulated experience with real patients
This discrepancy between the current post-marketing findings and prior clinical trial evidence highlights the significance of ongoing pharmacovigilance and real-world evidence studies in identifying rare but potentially serious adverse effects that may not be captured in pre-approval clinical trials
Philadelphia, PA: Elsevier
Some users notice appetite changes within the first week while weight loss related effects may take several weeks
