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Do not freeze Victoza and do not use Victoza if it has been frozen

Bupropion activates neurons in the hypothalamus that reduce appetite, while naltrexone blocks the brains counter-signal that would normally shut that appetite suppression off

Maintaining adequate fluid intake helps manage potential side effects such as constipation, which is common with GLP-1 medications, and supports overall physiological function

Management of endocrine diseasE: Are all GLP-1 agonist equal in the treatment of type 2 diabetes

Obes Surg 30(3):10381045

Moreover, GLP-1RA reduced the risk of MACE by 14% in the overall diabetic population, with an apparent greater effect in patients with established CV disease (16% vs 6% reduction, respectively), although the lack of significant interaction between subgroups does not allow to separate them [12]