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Whilst both berberine and GLP-1 agonists may influence glucose metabolism and body weight, they achieve these effects through entirely different pharmacological pathways

GLP-1 is a promising target for the treatment of depression because impaired neurogenesis ability and the reduction of neuronal differentiation leads to multiple depressive pathological symptoms

Thus we performed a systematic review with meta-analysis of existing head-to-head studies comparing the efficacy and safety of GLP-1 analogues with the DPP-4 inhibitors [28][37] to provide a more accurate and rigorous statistical analysis

For instance, tirzepatide, sold under the brand name Zepbound, binds to both GLP-1 and GIP receptors

Mast cell stabilisers such as sodium cromoglicate (available as nasal spray and eye drops) are an additional option, particularly for eye symptoms or as an adjunct in allergic rhinitis

The safety profile in unsupervised use, with research-grade (non-GMP) peptides, may differ substantially