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meningitidis activates both canonical and non-canonical pathways in the host, with predominance of the alternative caspase-3 mediated-GSDME activation in vitro in different cell lines (Tal et al., 2022) and of the GSDMD-dependent pathway in vivo in an intracisternal infected mouse model of meningitis (Pagliuca et al., 2024)
Mild soreness at the site can happen and typically fades within a day
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The Nano Microneedle Patch contains NIDDK-Tirzepatide in each patch
Oral: no viable (degradacin GI)
