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JR: Investigation, Methodology, Writing original draft

Additionally, significant oxidative stress alterations in the brain of rats in the central fatigue model indicate it as a potential key factor contributing to the manifestation of central fatigue-related symptoms

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Third, understand that current prescribing guidance has not changed

As a result, lipoic acid supplementation might protect neurons from some of the changes that lead to ALS (Liu 2008)

Studies in Drosophila have characterized Porcupine and Wntless to be essential for these steps, and their deficiency leads to phenotypes similar to those of Wingless (homolog of Wnt) mutants (van den Heuvel et al., 1993