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For MC1R specifically, melanocyte and melanoma-derived lines such as B16 are the traditional models

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Although these results hint at potential beyond-weight reproductive benefits (83), the extremely small sample size ( n = 28), open-label design, and lack of objective measurements for key biological intermediates (e.g., oocyte/embryo quality and endometrial receptivity), combined with controversies over the adequacy of the washout period, mean these conclusions should be viewed as exploratory rather than definitive

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There is also Rybelsus, the original oral semaglutide tablet, which has been around for several years