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Entering clinical trials in 2013, a phase 2 study published in 2018 showed significant and dose-dependent reductions in glycated hemoglobin (HbA1c) in Chinese patients with T2D 3

Within this signature, caspase-1 emerged as a top-tier biomarker of protease sensitivity (log 2 (fold change) = 1.28, P = 0.024

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