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But the PBAC said the sponsors proposal did not demonstrate the drugs cost-effectiveness compared to placebo coupled with diet and exercise, and was unclear on who would be eligible for the drug
The prescribing information notes that GLP-1 agonists have not been studied in patients with a history of pancreatitis, so whether to use them, and how closely to monitor, is an individualized decision rather than a blanket yes or no
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The launch comes as the patent on semaglutide the active ingredient in Novo Nordisks blockbuster drugs Ozempic and Wegovy expires in India this week, ending the companys exclusivity and opening the market to a wave of lower-cost generics
These include the catabolism of tyrosine, the synthesis of epinephrine from tyrosine (critical enzyme is dopamine -hydroxylase), the synthesis of carnitine, peptide hormone amidation, and the synthesis of bile acids
(2008) 294:L4656
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