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Although empagliflozin appeared to have less of a reno-protective effect in patients with HFpEF than with HFrEF, further analyses of EMPEROR-Preserved indicate that this may be related to the endpoint definition used (which excluded renal death and included 40% decrease in eGFR), with positive findings when using the renal endpoint from the DAPA-HF trial (which included renal death and 50% decrease in eGFR) [130, 131]

This satiety is particularly beneficial for those on semaglutide, as the medication suppresses appetite

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All three require subcutaneous injection once weekly