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JeanGilles emphasizes the importance of the dose escalation schedule
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Existing tree-based IRT models have been developed for binary and polytomous items within the Rasch models framework, which assume equal discrimination (i.e., the degree to which an item distinguishes between individuals with different levels of the latent construct) across items
Other agents in development include mazdutide , cagrilintide , survodutide, and orforglipron (an oral small-molecule GLP-1 agonist)
Possibly, though most of the TRIUMPH programme has completed recruitment
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