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NNMT catalyzes a reaction where it takes methyl groups from the bodys universal methyl donor (SAM) and transfers them onto vitamin B3, producing what is essentially a metabolic dead end

the NNMT inhibitor literature does not, with every published in-vivo study of 5-Amino-1MQ conducted in rodents and no NNMT inhibitor approved in any jurisdiction

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Inositols in Insulin Signaling and Glucose Metabolism. International journal of endocrinology vol

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But the honest assessment is that the clinical evidence does not support AOD 9604 as an effective standalone weight loss intervention