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PubMed Rotunda AM, Kolodney MS
The future likely involves both drugs coexisting as options for different patient profiles, similar to how semaglutide and tirzepatide both have their place in current practice
Questions sometimes arise about glp-1 long-term side effects, including whether gastrointestinal issues persist or whether risks accumulate
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Tirzepatide is a special kind of medicine that works on two receptors - glucose-dependent insulinotropic polypeptide (GIP) and GLP-1
Tell your prescribing clinician about persistent vomiting, dehydration, dizziness, weakness, very rapid weight loss, severe constipation, or inability to meet basic nutrition
From its initial use in the treatment of type 2 diabetes to its expansion to 12 indications such as obesity, cardiovascular disease, chronic kidney disease, and metabolic dysfunction related fatty liver disease (MASLD), the annual sales of GLP-1 drugs exceeded 100 billion dollars, and its research and development funding reached a historical peak of 21.72 million dollars in 2025
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