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Here is the caveat that most consumer articles omit: the tripeptide in that landmark study was AHK-Cu L-alanyl-L-histidyl-L-lysine copper, sometimes labeled copper tripeptide-3 not GHK-Cu
The role of glutathione-S-transferase in anti-cancer drug resistance
The treatment increased skin density and thickness, reduced fine lines and the depth of wrinkles, reduced photodamage and hyperpigmentation, improved skin clarity, and increased keratinocyte proliferation
Several factors likely contribute: the peptide's very short half-life, difficulty crossing the blood-brain barrier in meaningful quantities, small study sizes, differing endpoints (subjective reports versus objective polysomnography), and the placebo-sensitive nature of insomnia outcomes
It also underscores why replenishing glutathioneeither directly or through precursorsis a primary therapeutic target for neuroinflammation
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