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If the molecular chaperone functions of HSP70 and HSP90 are impaired by genetic deletion, mutation, or pharmacological inhibition, cells may become less efficient at recognizing, refolding, or clearing misfolded proteins, thereby compromising proteostasis recovery (Rutledge et al., 2022

I've had a dermo-oncologist on this podcast, we talked about collagen

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If the target is skin, hair, tendons, or muscle tissue, the focus is structural (Glow)

Studies have demonstrated that the overactivation of microglia into the M1 phenotype induces increased secretion of pro-inflammatory cytokines, and their excessive accumulation in the brain may impair microglial immunologic function and exacerbate AD progression [54]