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A novel arsenical has antitumor activity toward As 2 O 3 -resistant and MRP1/ABCC1-overexpressing cell lines
(7) also demonstrated that UA has a particularly significant effect on short-chain acylcarnitine, an intermediate in the fatty acid oxidation process, indicating increased efficiency in fatty acid oxidation (63)
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The compounds listed in Table S4, tested at various times and at concentrations with statistically significant effect, induce eryptosis dependent on calcium, ceramide, and ROS
JAMA Dermatol 158, 542546
Thus, these conserved interactions promote the formation and stability of the bypass motif, which is a key structural determinant for the high potency of Amy analogues at AMYRs 15,16
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