The beneficial effects of GLP-1 RAs on HRQoL and other outcomes in HFpEF are likely due to pleiotropic impacts, related or not to weight reduction, such as decongestion (mainly due to the reduction of increased plasma volume associated with obesity and epicardial constrain), reverse cardiac remodelling (mainly due to the decrease in epicardial fat and regression of left atrial and LV myopathy, lowering intracardiac pressure) and anti-inflammatory actions, among others
It often causes rigidness and tremors, slow movement, and loss of balance
Philbert MA, Beiswanger CM, Waters DK, Reuhl KR, Lowndes HE
1 Memory and Cognition Acetyl L-carnitine may have some brain-boosting benefits, especially for the aging community
I strongly recommend an anti-inflammatory, low insulin-provoking (i.e
GLP-1R has been densely found in the choroid plexus, suggesting the possibility it may play a role in sodium transport and cerebrospinal fluid (CSF) production [102]