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A dedicated cardiovascular outcomes trial (CVOT) for orforglipron has not been mandated by the FDA for initial approval but may be required or conducted voluntarily as a post-marketing commitment, following the precedent set by the SELECT trial for semaglutide

So, should people with RA consider weight loss drugs

The other creates short-term appetite or energy shifts with limited long-term data

Journal of child and adolescent psychopharmacology , 31 (3), 187196

These medicines include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro), which is a dual GIP/GLP-1 receptor agonist rather than a pure GLP-1 agonist

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