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Phase 2 trial (NEJM 2023) randomized 338 adults with obesity to retatrutide doses from 1 mg to 12 mg/week
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We also used a self-controlled case series design [19], which comprised of new users of GLP-1 RAs ( n = 85,717 ) or SGLT-2 inhibitors ( n = 78,366 ) or DPP-4 inhibitors ( n = 35,762) from 2014 to 2022
Patients with hypertension should receive appropriate first-line antihypertensive therapy according to NICE hypertension guidelines (NG136), which recommend ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, or thiazide-like diuretics as initial treatment depending on age, ethnicity, and comorbidities
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