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doi: 10.3389/fimmu.2013.00470 54 De CandiaP.PrattichizzoF.GaravelliS.MatareseG

GRB2 depletion leads to fork collapse, cytosolic DNA accumulation, cGASSTING activation, and increased PARPi sensitivity

The first and best-characterized mechanism is the AMPK pathway

Background fluorescence was determined in each individual experiment with cells exposed to Triton (1%) and subtracted from all other values

4 Oxidative stress in gastric cancer 4.1 Gastric carcinogenesis Under oxidative stress, increased ROS in cells may harm tissues and trigger carcinogenesis, especially in the gastrointestinal system ( Figure 3 )