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Other studies have described reduced tumor growth and angiogenesis-related markers in experimental systems, potentially through modulation of Akt- and NF-B-associated signaling responses [82]

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None has been established as the operative mechanism

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demonstrated that ganglioside GM1, a neuroprotective sphingolipid, alleviates the severity of HACE by attenuating oxidative stress and the inflammatory response through activation of the PI3K/AKT-Nrf2 pathway in HACE patients (79)

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